The fundamental doctrines of Taoism, such as the Tao-born moral education, natural inaction, tranquility and few desires, gentleness and non-contention, longevity and longevity, etc., all originate from the Supreme Daodejing. When Zhang Daoling, the founder of the Taoist sect, established the Taoist sect, he took the Five Thousand Words (Daodejing) as the holy book, and wrote Laozi Xianger Notes to explain the main teachings and cultivation principles of Taoism, and initially established the Taoist doctrine and thought system, using the name "Zhengyi" to indicate that the teaching theory advocated was the Supreme True One and Only Orthodox Religion. Moreover, the Taoist classics and the writings of many Taoist masters were fully developed or necessary interpretations were made based on the holy book "Daodejing". The Nanhua Sutra and Chongxu Sutra, which are respected by Taoism, inherit the ideas of the Daode Sutra of the Supreme Being, enrich and expound the Taoist ideas of self-cultivation, spiritual freedom, meditation and health preservation, and the transformation of immortals, so that the Taoist doctrines that emphasize rationality have been passed on to the doctrines of Taoism under the inheritance and exposition of the later generations of high Taoists, and they have become one with each other. The Taiping Jing is based on religious education, and fully explains the creation theory of the Daode Sutra that the "Tao" gave birth to the heaven and earth and all things, and the doctrine of the Daode Sutra that "the way of heaven reduces the surplus and supplements the deficiency". The Taoist Master Ge Hong talks about the art of immortals, which should also belong to the system of the Supreme Being. The Duren Jing takes "the immortal way values ​​life and saves people without limit" as its main purpose, which embodies the fundamental tenet of the Daode Sutra. In short, the doctrines and ideas of Taoism are all based on the Daode Sutra, so Taoism respects the Daode Sutra as a sacred book.

道教的教理教义，如道生德育、自然无为、清静寡欲、柔弱不争、长生久视等根本宗义，皆源出于太上《道德真经》。祖天师张道陵建立道教教团之时，即以五千文(《道德真经》)为圣典，并作《老子想尔注》，阐说道要教旨和修行准则，初步建立起道教教义思想体系，以“正一”之名来表明所倡行的教化学说是太上真一不二的正教。而且，道教的经典和许多高道真人的著述也都根据《道德真经》这部圣典加以充分的发挥，或作必要的演绎。道教尊奉的《南华真经》和《冲虚真经》，承扬太上《道德真经》的思想，对道教修身体道、精神逍遥、坐忘养生、神仙变化等思想以丰富和阐扬，使偏重理性的道家学说在后世高道的继承阐扬下，过渡到道教的教义学说，彼此而打成一片。《太平经》以宗教教化而立论，对《道德真经》“道”生化天地万物的创世说和《道德真经》“天之道损有余而补不足”的教义作了充分阐释。葛洪真人畅玄而讲神仙之术，亦当属于太上道家之系统。《度人经》以“仙道贵生，无量度人”为主旨，正体现了《道德真经》的根本宗义。总之，道教的教义思想无不根本于《道德真经》，因而道教尊《道德真经》为圣典。